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Electroneutral (NBCn1) and electrogenic (NBCe1) isoforms of the Na(+)-HCO3(-) cotransporter (NBC) coexist in the heart. We studied the expression and function of these isoforms in hearts of Wistar and spontaneously hypertensive rats (SHR), elucidating the direct implication of the renin-angiotensin system in the NBC regulation.

cardiovascular research

Reduced sarcolemmal expression and function of the NBCe1 isoform of the Na+–HCO3− cotransporter in hypertrophied cardiomyocytes of spontaneously hypertensive rats: role of the renin–angiotensin system