Open AccessA transgenic mouse model for the simultaneous monitoring of ANF and BNP gene activity during heart development and disease
Author(s) -
I. A. Sergeeva,
Ingeborg B. Hooijkaas,
Ingeborg van der Made,
Willeke M. C. Jong,
Esther E. Creemers,
Vincent M. Christoffels
Publication year - 2013
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvt228
Subject(s) - genetically modified mouse , heart failure , medicine , transgene , heart disease , cardiology , disease , gene expression , gene , biology , genetics
The expression of Nppa (ANF) and Nppb (BNP) marks the chamber myocardium in the embryo, and both genes serve as early and accurate markers for hypertrophy and heart failure. Non-invasive visualization of Nppa-Nppb expression in living mice would enable to evaluate the disease state during the course of time in heart disease models. We sought to develop a method to assess the pattern and level of Nppa and Nppb expression within living mice.
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