Open AccessThe galectin-3/RAGE dyad modulates vascular osteogenesis in atherosclerosis
Author(s) -
Stefano Menini,
Carla Iacobini,
Pier Carlo Ricci,
Claudia Blasetti Fantauzzi,
Laura Salvi,
Carlo Pesce,
Michela Relucenti,
Giuseppe Familiari,
Maurizio Taurino,
Giuseppe Pugliese
Publication year - 2013
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvt206
Subject(s) - rage (emotion) , medicine , galectin 3 , dyad , galectin 1 , endocrinology , cardiology , neuroscience , biology , cancer research , psychology , social psychology
Vascular calcification correlates with inflammation and plaque instability in a dual manner, depending on the spotty/granular (micro) or sheet-like/lamellated (macro) pattern of calcification. Modified lipoproteins trigger both inflammation and calcification via receptors for advanced lipoxidation/glycation endproducts (ALEs/AGEs). This study compared the roles of galectin-3 and receptor for AGEs (RAGE), two ALEs/AGEs-receptors with diverging effects on inflammation and bone metabolism, in the process of vascular calcification.
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