Open AccessEpicardial calcineurin–NFAT signals through Smad2 to direct coronary smooth muscle cell and arterial wall development
Author(s) -
Yang Jin,
Miriam Zeini,
ChiehYu Lin,
Chien-Jung Lin,
Yiqin Xiong,
Ching Shang,
Pei Han,
Wei Li,
Thomas Quertermous,
Bin Zhou,
Ching-Pin Chang
Publication year - 2013
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvt197
Subject(s) - nfat , calcineurin , myocyte , medicine , cardiology , microbiology and biotechnology , biology , transplantation
Congenital coronary artery anomalies produce serious events that include syncope, arrhythmias, myocardial infarction, or sudden death. Studying the mechanism of coronary development will contribute to the understanding of the disease and help design new diagnostic or therapeutic strategies. Here, we characterized a new calcineurin-NFAT signalling which specifically functions in the epicardium to regulate the development of smooth muscle wall of the coronary arteries.
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