Open AccessLoss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation
Author(s) -
James H. King,
Chandu Wickramarachchi,
Krystine Kua,
Yuan Du,
Kamalan Jeevaratnam,
Hugh R. Matthews,
Andrew A. Grace,
Christopher Huang,
James A. Fraser
Publication year - 2013
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvt141
Subject(s) - medicine , cyclopiazonic acid , nav1.5 , endocrinology , depolarization , extracellular , patch clamp , homeostasis , membrane potential , chemistry , sodium channel , electrophysiology , calcium , sodium , biochemistry , organic chemistry
Recent studies reported slowed conduction velocity (CV) in murine hearts homozygous for the gain-of-function RyR2-P2328S mutation (RyR2(S/S)) and associated this with an increased incidence of atrial and ventricular arrhythmias. The present experiments determined mechanisms contributing to the reduced atrial CV.
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