Open AccessRETRACTED: Transcription factor Krüppel-like factor 2 plays a vital role in endothelial colony forming cells differentiation
Author(s) -
Yimeng Song,
Xiaoxia Li,
Dawei Wang,
Chenglai Fu,
Zhenjiu Zhu,
Ming-Hui Zou,
Yi Zhu
Publication year - 2013
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvt113
Subject(s) - klf2 , progenitor cell , vascular endothelial growth factor , angiogenesis , microbiology and biotechnology , vasculogenesis , klf4 , ampk , biology , vascular endothelial growth factor a , stem cell , gene knockdown , transcription factor , cellular differentiation , cancer research , protein kinase a , kinase , sox2 , cell culture , biochemistry , gene , genetics , vegf receptors
Endothelial colony forming cells (ECFCs) participate in post-natal vasculogenesis. We previously reported that vascular endothelial growth factor (VEGF) promotes human ECFC differentiation through AMP-activated protein kinase (AMPK) activation. However, the mechanisms underlying transcriptional regulation of ECFC differentiation still remain largely elusive. Here, we investigated the role of transcription factor Krüppel-like factor 2 (KLF2) in the regulation of ECFC function.
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