Open AccessInducible re-expression of HEXIM1 causes physiological cardiac hypertrophy in the adult mouse
Author(s) -
Monica M. Montano,
Candida L. Desjardins,
Yong Qui Doughman,
Yee-Hsee Hsieh,
Yanduan Hu,
Heather M. Bensinger,
Connie Wang,
Julian E. Stelzer,
Thomas E. Dick,
Brian D. Hoit,
Margaret P. Chandler,
Xin Yu,
Michiko Watanabe
Publication year - 2013
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvt086
Subject(s) - cardiac hypertrophy , myocardial hypertrophy , transcription factor , cardiac function curve , growth factor , medicine , microbiology and biotechnology , biology , endocrinology , muscle hypertrophy , chemistry , biochemistry , heart failure , gene , receptor
The transcription factor hexamethylene-bis-acetamide-inducible protein 1 (HEXIM1) regulates myocardial vascularization and growth during cardiogenesis. Our aim was to determine whether HEXIM1 also has a beneficial role in modulating vascularization, myocardial growth, and function within the adult heart.
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