Open AccessMetallothionein-dependent up-regulation of TGF-β2 participates in the remodelling of the myxomatous mitral valve
Author(s) -
Alexia Hulin,
Christophe Deroanne,
Charles Lambert,
Bruno Dumont,
Vincent Castronovo,
Jean-Olivier Defraigne,
Betty Nusgens,
Marc Radermecker,
Alain Colige
Publication year - 2011
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvr337
Subject(s) - versican , extracellular matrix , transforming growth factor , microbiology and biotechnology , biology , transforming growth factor beta , pdgfb , immunohistochemistry , transcriptome , gene expression , pathology , immunology , gene , growth factor , medicine , receptor , proteoglycan , genetics , platelet derived growth factor receptor
Although an excessive extracellular matrix remodelling has been well described in myxomatous mitral valve (MMV), the underlying pathogenic mechanisms remain largely unknown. Our goal was to identify dysregulated genes in human MMV and then to evaluate their functional role in the progression of the disease.
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