Mutations of ventricular essential myosin light chain disturb myosin binding and sarcomeric sorting | Zendy

Janine Lossie | Zendy; Dmitry S. Ushakov | Zendy; Michael A. Ferenczi | Zendy; Sascha Werner | Zendy; Sandro Keller | Zendy; H. Haase | Zendy; Ingo Morano | Zendy

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Mutations of ventricular essential myosin light chain disturb myosin binding and sarcomeric sorting

Author(s) -

Janine Lossie,

Dmitry S. Ushakov,

Michael A. Ferenczi,

Sascha Werner,

Sandro Keller,

H. Haase,

Ingo Morano

Publication year - 2011

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvr320

Subject(s) - myosin , myosin light chain kinase , immunoglobulin light chain , myh7 , microbiology and biotechnology , chemistry , medicine , biology , genetics , antibody

We tested the hypothesis that mutations in the human ventricular essential myosin light chain (hVLC-1) that are associated with hypertrophic cardiomyopathy (HCM) affect protein structure, binding to the IQ1 motif of cardiac myosin heavy chain (MYH) and sarcomeric sorting in neonatal cardiomyocytes.

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