Open AccessPI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism
Author(s) -
Daniela Carnevale,
Carmine Vecchione,
Giada Mascio,
Giovanni Esposito,
Giuseppe Cifelli,
Katiuscia Martinello,
Alessandro Landolfi,
Giulio Selvetella,
Paolo Grieco,
Antonio Damato,
Elio Franco,
Hannelore Haase,
Angelo Maffei,
Elisa Ciraolo,
Sergio Fucile,
Giacomo Frati,
Orazio Mazzoni,
Emilio Hirsch,
Giuseppe Lembo
Publication year - 2011
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvr288
Subject(s) - l type calcium channel , calcium channel , blood pressure , pi3k/akt/mtor pathway , calcium , pharmacology , protein kinase b , mechanism (biology) , voltage dependent calcium channel , medicine , chemistry , endocrinology , phosphorylation , signal transduction , biochemistry , philosophy , epistemology
The lipid and protein kinase phosphoinositide 3-kinase γ (PI3Kγ) is abundantly expressed in inflammatory cells and in the cardiovascular tissue. In recent years, its role in inflammation and in cardiac function and remodelling has been unravelled, highlighting the beneficial effects of its pharmacological inhibition. Furthermore, a role for PI3Kγ in the regulation of vascular tone has been emphasized. However, the impact of this signalling in the control of blood pressure is still poorly understood. Our study investigated the effect of a selective inhibition of PI3Kγ, obtained by using two independent small molecules, on blood pressure. Moreover, we dissected the molecular mechanisms involved in control of contraction of resistance arteries by PI3Kγ.
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