Open AccessTie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells
Author(s) -
Kakali Sarkar,
Sergio Rey,
Xianjie Zhang,
Raul Sebastian,
Guy P. Marti,
Karen Fox-Talbot,
Amanda V. Cardona,
Junkai Du,
Yee Sun Tan,
Lixin Liu,
Frank Lay,
Frank J. Gonzalez,
John W. Harmon,
Gregg L. Semenza
Publication year - 2011
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvr282
Subject(s) - homing (biology) , bone marrow , angiopoietin receptor , neovascularization , knockout mouse , angiogenesis , microbiology and biotechnology , cancer research , immunology , medicine , pathology , biology , receptor , ecology
Hypoxia-inducible factor 1 (HIF-1) is a heterodimer composed of HIF-1α and HIF-1β subunits. HIF-1 is known to promote tissue vascularization by activating the transcription of genes encoding angiogenic factors, which bind to receptors on endothelial cells (ECs) and bone marrow-derived angiogenic cells (BMDACs). In this study, we analysed whether HIF-1 activity in the responding ECs and BMDACs is also required for cutaneous vascularization during burn wound healing.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom