Open AccessContributions of ACE and mast cell chymase to endogenous angiotensin II generation and leucocyte recruitment in vivo
Author(s) -
Laura Piqueras,
Yafa Naim Abu Nabah,
Paula Escudero,
J.I. Blanes,
Peter J. Jose,
Esteban Morcillo,
MaríaJesús Sanz
Publication year - 2011
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvr147
Subject(s) - chymase , enalapril , losartan , angiotensin ii receptor type 1 , mast cell , angiotensin ii , in vivo , bradykinin , angiotensin converting enzyme , ace inhibitor , medicine , endocrinology , receptor , degranulation , renin–angiotensin system , endothelium , chemistry , pharmacology , biology , immunology , blood pressure , microbiology and biotechnology
In vitro studies suggest that mast cell chymase (MCP) is more important than angiotensin-converting enzyme (ACE) for generating angiotensin II (Ang II) within the cardiovascular system. We investigated in vivo the relative contributions of ACE and MCP to leucocyte recruitment induced by endogenously generated Ang II.
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