Open AccessSirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells
Author(s) -
Alexander Breitenstein,
Sokrates Stein,
Erik W. Holy,
Giovanni G. Camici,
Christine Lohmann,
Alexander Akhmedov,
Remo D. Spescha,
Peter J. Elliott,
Christoph Westphal,
Christian M. Matter,
Thomas F. Lüscher,
Felix C. Tanner
Publication year - 2010
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvq339
Subject(s) - tissue factor , in vivo , tissue factor pathway inhibitor , microbiology and biotechnology , mapk/erk pathway , biology , nfkb1 , chemistry , signal transduction , transcription factor , coagulation , medicine , biochemistry , gene
The mammalian silent information regulator-two 1 (Sirt1) blunts the noxious effects of cardiovascular risk factors such as type 2 diabetes mellitus and obesity. Nevertheless, the role of Sirt1 in regulating the expression of tissue factor (TF), the key trigger of coagulation, and arterial thrombus formation remains unknown.
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