Open AccessAblation of phospholamban and sarcolipin results in cardiac hypertrophy and decreased cardiac contractility
Author(s) -
Mayilvahanan Shanmugam,
Shumin Gao,
Chull Hong,
Nadezhda Fefelova,
Martha C. Nowycky,
LaiHua Xie,
Muthu Periasamy,
Gopal J. Babu
Publication year - 2010
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvq294
Subject(s) - phospholamban , serca , contractility , medicine , pressure overload , cardiac function curve , heart failure , muscle hypertrophy , cardiology , endocrinology , endoplasmic reticulum , chemistry , cardiac hypertrophy , atpase , biology , microbiology and biotechnology , biochemistry , enzyme
Improving the sarco(endo)plasmic reticulum (SR) Ca(2+)-ATPase (SERCA) function has clinical implications in treating heart failure. The present study aimed to determine the effect of constitutive activation of the SERCA pump on cardiac contractility in normal mice and during pressure-overload-induced cardiac hypertrophy.
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