Open AccessRegulation of monocyte subset systemic levels by distinct chemokine receptors controls post-ischaemic neovascularization
Author(s) -
Clément Cochain,
Mathieu P. Rodero,
José Vilar,
Alice Récalde,
Adèle Richart,
Céline Loinard,
Yasmine Zouggari,
Coralie L. Guérin,
Micheline Duriez,
Christophe Combadière,
Lucie Poupel,
Bernard Lévy,
Ziad Mallat,
Christophe Combadière,
JeanSébastien Silvestre
Publication year - 2010
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvq153
Subject(s) - ccr2 , monocyte , cx3cr1 , ccl2 , cc chemokine receptors , chemokine , ccl5 , chemokine receptor , cx3cl1 , immunology , angiogenesis , neovascularization , medicine , cancer research , biology , inflammation , immune system , t cell , il 2 receptor
Monocyte systemic levels are known to be a major determinant of ischaemic tissue revascularization, but the mechanisms mediating mobilization of different monocyte subsets-Ly6C(hi) and Ly6C(lo)-to the blood and their respective role in post-ischaemic neovascularization are not clearly understood. Here, we hypothesized that distinct chemokine/chemokine receptor pathways, namely CCL2/CCR2, CX3CL1/CX3CR1, and CCL5/CCR5, differentially control monocyte subset systemic levels, and might thus impact post-ischaemic vessel growth.
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