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Caloric restriction (CR) and female gender attenuate oxidative damage and improve vascular endothelium-dependent relaxation (EDR). Multiple mechanisms that ameliorate vascular O(2)(*-) could enhance the NO(*)/O(2)(*-) balance and thus improve EDR. The aim of this study is to compare the effects of short-term (2 weeks) CR and gender on molecular mechanisms involved in NO(*)/O(2)(*-) balance and EDR.

Gender-specific effects of caloric restriction on the balance of vascular nitric oxide and superoxide radical