Open AccessGender-specific effects of caloric restriction on the balance of vascular nitric oxide and superoxide radical
Author(s) -
Shih-Hsuan Chou,
Yung-Chen Lee,
Chiu-Feng Huang,
Yuren Wang,
HuangPing Yu,
YingTung Lau
Publication year - 2010
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvq095
Subject(s) - p22phox , endocrinology , medicine , enos , nox4 , nadph oxidase , nitric oxide , superoxide , nitric oxide synthase type iii , chemistry , nitric oxide synthase , oxidative stress , ghrelin , biology , biochemistry , hormone , enzyme
Caloric restriction (CR) and female gender attenuate oxidative damage and improve vascular endothelium-dependent relaxation (EDR). Multiple mechanisms that ameliorate vascular O(2)(*-) could enhance the NO(*)/O(2)(*-) balance and thus improve EDR. The aim of this study is to compare the effects of short-term (2 weeks) CR and gender on molecular mechanisms involved in NO(*)/O(2)(*-) balance and EDR.
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