Open AccessThe histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces cardiac arrhythmias in dystrophic mice
Author(s) -
Claudia Colussi,
Roberta Berni,
Jessica Rosati,
Stefania Straino,
Serena Vitale,
Francesco Spallotta,
Silvana Baruffi,
Leonardo Bocchi,
Francesca Delucchi,
Stefano Rossi,
Monia Savi,
Dante Rotili,
Federico Quaini,
Emilio Macchi,
Donatella Stilli,
Ezio Musso,
Antonello Mai,
Carlo Gaetano,
Maurizio C. Capogrossi
Publication year - 2010
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvq035
Subject(s) - medicine , sodium channel , valproic acid , histone deacetylase inhibitor , endocrinology , chemistry , pharmacology , histone deacetylase , sodium , biochemistry , histone , organic chemistry , epilepsy , gene , psychiatry
The effect of histone deacetylase inhibitors on dystrophic heart function is not established. To investigate this aspect, dystrophic mdx mice and wild-type (WT) animals were treated 90 days either with suberoylanilide hydroxamic acid (SAHA, 5 mg/kg/day) or with an equivalent amount of vehicle.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom