Open AccessCardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway
Author(s) -
Narasimman Gurusamy,
István Lekli,
Subhendu Mukherjee,
Diptarka Ray,
Md. Kaimul Ahsan,
Mihaela Gherghiceanu,
Lawrence M. Popescu,
Dipak K. Das
Publication year - 2009
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvp384
Subject(s) - resveratrol , autophagy , pi3k/akt/mtor pathway , cardioprotection , mtorc2 , protein kinase b , chemistry , pharmacology , programmed cell death , microbiology and biotechnology , phosphorylation , apoptosis , biology , mtorc1 , biochemistry , ischemia , medicine
On the basis of our previous reports that cardioprotection induced by ischaemic preconditioning induces autophagy and that resveratrol, a polyphenolic antioxidant present in grapes and red wine induces preconditioning-like effects, we sought to determine if resveratrol could induce autophagy.
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