Open AccessCB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes
Author(s) -
Partha Mukhopadhyay,
Mohanraj Rajesh,
Sándor Bátkai,
Vivek Patel,
Yoshihiro Kashiwaya,
Lucas Liaudet,
Oleg V. Evgenov,
Ken Mackie,
György Haskó,
Pál Pacher
Publication year - 2009
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvp369
Subject(s) - cannabinoid receptor , oxidative stress , cardiomyopathy , doxorubicin , receptor , cannabinoid , medicine , programmed cell death , pharmacology , cancer research , heart failure , biology , apoptosis , chemotherapy , biochemistry , agonist
Here we investigated the mechanisms by which cardiovascular CB1 cannabinoid receptors may modulate the cardiac dysfunction, oxidative stress, and interrelated cell death pathways associated with acute/chronic cardiomyopathy induced by the widely used anti-tumour compound doxorubicin (DOX).
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