Open AccessRole of FRNK tyrosine phosphorylation in vascular smooth muscle spreading and migration
Author(s) -
Yevgeniya E. Koshman,
Steven J. Engman,
Taehoon Kim,
Rekha Iyengar,
Kyle K. Henderson,
Allen M. Samarel
Publication year - 2009
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvp322
Subject(s) - vascular smooth muscle , focal adhesion , phosphorylation , tyrosine phosphorylation , microbiology and biotechnology , tyrosine , tyrosine kinase , proto oncogene tyrosine protein kinase src , kinase , cell migration , biology , signal transduction , smooth muscle , cancer research , cell , endocrinology , biochemistry
Focal adhesion kinase (FAK) and its autonomously expressed, C-terminal inhibitor FAK-related non-kinase (FRNK), are important regulators of vascular smooth muscle cell (VSMC) spreading and migration. However, the mechanisms of FRNK-mediated inhibition of FAK-dependent signalling are not fully defined. The aim of this study was to determine the potential role of FRNK tyrosine phosphorylation in regulating these processes.
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