Open AccessLOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells
Author(s) -
Koichi Sugimoto,
Toshiyuki Ishibashi,
Tatsuya Sawamura,
Nobutaka Inoue,
Masashi Kamioka,
Hironori Uekita,
Hiroshi Ohkawara,
Takayuki Sakamoto,
Nobuo Sakamoto,
Yasuo Okamoto,
Yoh Takuwa,
Akemi Kakino,
Yoshiko Fujita,
Takeshi Tanaka,
Tamio Teramoto,
Yukio Maruyama,
Yasuchika Takeishi
Publication year - 2009
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvp177
Subject(s) - rhoa , rac1 , matrix metalloproteinase , chemistry , low density lipoprotein , microbiology and biotechnology , lipoprotein , scavenger receptor , receptor , biochemistry , signal transduction , biology , cholesterol
RhoA and Rac1 activation plays a key role in endothelial dysfunction. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a major receptor for oxidized low-density lipoprotein (ox-LDL) in endothelial cells (ECs). Membrane type 1 matrix metalloproteinase (MT1-MMP) has been shown to be involved in atherogenesis. This study was conducted to investigate the role of the LOX-1-MT1-MMP axis in RhoA and Rac1 activation in response to ox-LDL in ECs.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom