Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion | Zendy

Alexander Brill | Zendy; Anil K. Chauhan | Zendy; Matthias Canault | Zendy; Melanie Walsh | Zendy; Wolfgang Bergmeier | Zendy; Denisa D. Wagner | Zendy

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Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion

Author(s) -

Alexander Brill,

Anil K. Chauhan,

Matthias Canault,

Melanie Walsh,

Wolfgang Bergmeier,

Denisa D. Wagner

Publication year - 2009

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvp176

Subject(s) - microbiology and biotechnology , oxidative stress , platelet activation , platelet , receptor , chemistry , p38 mitogen activated protein kinases , biology , kinase , protein kinase a , biochemistry , immunology

Oxidative stress accompanies inflammatory and vascular diseases. The objective of this study was to explore whether reactive oxygen species can activate shedding of platelet receptors and thus suppress platelet function.

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