Open AccessA transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome
Author(s) -
Kirstine Calløe,
Jonathan M. Cordeiro,
José M. Di Diego,
R. Scott Hansen,
Morten Grunnet,
SørenPeter Olesen,
Charles Antzelevitch
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvn339
Subject(s) - cardiac transient outward potassium current , endocardium , medicine , repolarization , brugada syndrome , activator (genetics) , cardiology , ventricular tachycardia , endocrinology , patch clamp , chemistry , electrophysiology , receptor
Transient outward potassium current (I(to)) is thought to be central to the pathogenesis of the Brugada syndrome (BrS). However, an I((to)) activator has not been available with which to validate this hypothesis. Here, we provide a direct test of the hypothesis using a novel I(to) activator, NS5806.
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