Open AccessType 2 diabetes severely impairs structural and functional adaptation of rat resistance arteries to chronic changes in blood flow
Author(s) -
Eric J. Belin de Chantemèle,
Emilie Vessières,
AnneLaure Guihot,
Bertrand Toutain,
Maud Maquignau,
Laurent Loufrani,
Daniel Henrion
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvn334
Subject(s) - medicine , endocrinology , mesenteric arteries , oxidative stress , endothelial dysfunction , endothelium , vasodilation , diabetes mellitus , type 2 diabetes , artery , chemistry
Endothelial dysfunction in resistance arteries (RAs) leads to end-organ damage in type 2 diabetes. Remodelling of RAs in response to chronic increases in blood flow depends on the integrity of the endothelium. Since type 2 diabetes impairs endothelial sensitivity to flow and increases oxidative stress, we hypothesized that flow-induced remodelling in RAs would be impaired in diabetes. Thus, we studied the structural and functional adaptation of RAs from Zucker diabetic fatty (ZDF) and lean Zucker (LZ) rats to chronic changes in flow.
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