Open AccessOmega-3 polyunsaturated fatty acids inhibit transient outward and ultra-rapid delayed rectifier K+currents and Na+current in human atrial myocytes
Author(s) -
GuiRong Li,
HaiYing Sun,
Xiaohua Zhang,
LikCheung Cheng,
ShuiWah Chiu,
HungFat Tse,
Chu-Pak Lau
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvn322
Subject(s) - docosahexaenoic acid , eicosapentaenoic acid , myocyte , polyunsaturated fatty acid , chemistry , patch clamp , medicine , inward rectifier potassium ion channel , potassium channel , cardiac transient outward potassium current , atrial myocytes , endocrinology , fatty acid , biochemistry , ion channel , receptor
The omega-3 (n-3) polyunsaturated fatty acids (omega-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from fish oil were recently reported to have an anti-atrial fibrillation effect in humans; however, the ionic mechanisms of this effect are not fully understood. The present study was designed to determine the effects of EPA and DHA on transient outward and ultra-rapid delayed rectifier potassium currents (I(to) and I(Kur)) and the voltage-gated sodium current (I(Na)) in human atrial myocytes.
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