Open AccessEndothelial CD81 is a marker of early human atherosclerotic plaques and facilitates monocyte adhesion
Author(s) -
Jakub Rohlena,
Oscar L. Volger,
Jaap D. van Buul,
Liesbeth H.P. Hekking,
Janine M. van Gils,
Peter I. Bonta,
Ruud D. Fontijn,
Jan A. Post,
Peter L. Hordijk,
Anton J.G. Horrevoets
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvn256
Subject(s) - cell adhesion molecule , downregulation and upregulation , microbiology and biotechnology , endothelium , intercellular adhesion molecule 1 , atheroma , cd81 , tetraspanin , monocyte , biology , e selectin , cell adhesion , adhesion , chemistry , immunology , medicine , cell , biochemistry , endocrinology , virus , hepatitis c virus , organic chemistry , gene
In a recent report, we established at the genome-wide level those genes that are specifically upregulated in the endothelium of atherosclerotic plaques in human arteries. As the transcriptome data revealed that mRNA for the tetraspanin family member CD81 is significantly and specifically upregulated in the endothelium overlying early atheroma, we set out to validate these results on the protein level, and investigate the functional consequences of CD81 upregulation.
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