Open AccessHomocysteine modulates the effect of simvastatin on expression of ApoA-I and NF- B/iNOS
Author(s) -
Leonie G. Mikael,
Rima Rozen
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvn157
Subject(s) - simvastatin , homocysteine , inflammation , apolipoprotein b , nf κb , endocrinology , medicine , cholesterol , chemistry , statin , nfkb1 , biochemistry , transcription factor , gene
Statins can ameliorate atherosclerosis by inhibition of cholesterol biosynthesis or by modulation of inflammation. In earlier work, we showed that homocysteine (Hcy) reduced synthesis of apolipoprotein A-I (ApoA-I). Our goal in this study was to determine whether Hcy could interfere with the ability of simvastatin to increase ApoA-I synthesis or to modify statin-dependent regulation of inflammatory factors.
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