Open AccessCoupling erythropoietin secretion to mesenchymal stromal cells enhances their regenerative properties
Author(s) -
Ian B. Copland,
E. Marc Jolicœur,
MarcAntoine Gillis,
Jessica Cuerquis,
Nicoletta Eliopoulos,
Borhane Annabi,
Angelo Calderone,
JeanFrançois Tanguay,
Anique Ducharme,
Jacques Galipeau
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvn090
Subject(s) - mesenchymal stem cell , paracrine signalling , erythropoietin , autocrine signalling , stromal cell , matrigel , in vivo , cardioprotection , transplantation , angiogenesis , microbiology and biotechnology , medicine , cancer research , immunology , biology , myocardial infarction , receptor
Mesenchymal stromal cells (MSCs) possess intrinsic features that identify them as useful for treating ischaemic syndromes. Poor in vivo survival/engraftment of MSCs, however, limits their overall effectiveness. In this work, we tested whether genetically engineering MSCs to secrete erythropoietin (Epo) could represent a better therapeutic platform than MSCs in their native form.
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