Open AccessSelective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate
Author(s) -
A. I. Duenas,
Mario Alberto Burgos-Aceves,
Isabel FernándezPisonero,
Cristina Gómez,
Antonio Orduña,
Mariano Sánchez Crespo,
Carmen GarcíaRodríguez
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvn087
Subject(s) - sphingosine 1 phosphate , microbiology and biotechnology , tlr2 , signal transduction , sphingosine , receptor , biology , lipid signaling , chemistry , tlr4 , biochemistry
Vascular inflammation is a major atherogenic factor and Toll-like receptor (TLR) 2 ligands, including bacterial and serum lipoproteins, seem to be involved in atherogenesis. On this basis, we analysed the effect of lipoproteins and different lipid components on TLR2-dependent signalling.
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