Open AccessVasoconstrictor effect of aldosterone via angiotensin II type 1 (AT1) receptor: possible role of AT1 receptor dimerization
Author(s) -
Masahiro Yamada,
Motoi Kushibiki,
Tomohiro Osanai,
Hirofumi Tomita,
Kazuhiro Okumura
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvn064
Subject(s) - angiotensin ii receptor type 1 , angiotensin ii , receptor , medicine , renin–angiotensin system , chemistry , endocrinology , aldosterone , angiotensin receptor , pharmacology , blood pressure
We recently demonstrated that aldosterone induces a non-genomic vasoconstrictor effect on rat coronary arterioles and that this effect was blocked by angiotensin II type 1 receptor (AT1) blockers. Intracellular transglutaminase enhances AT1 signalling by cross-linking AT1 homodimers. The purpose of this study was to confirm the AT1-dependency of the vasoconstrictor effect of aldosterone using AT1a knockout (AT1aKO) mice and to investigate the role of intracellular transglutaminase and AT1 dimerization in this effect.
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