Open AccessEffects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart
Author(s) -
David A. Brown,
Miguel A. Aon,
Fadi G. Akar,
Ting Liu,
Nicolas Sorarrain,
Brian O’Rourke
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvn053
Subject(s) - ischemia , inotrope , medicine , contraction (grammar) , reperfusion therapy , calcium , mitochondrial permeability transition pore , cardiology , reperfusion injury , anesthesia , chemistry , pharmacology , biochemistry , apoptosis , programmed cell death
Recent evidence indicates that the activity of energy-dissipating ion channels in the mitochondria can influence the susceptibility of the heart to ischaemia-reperfusion injury. In this study, we describe the effects of 4'-chlorodiazepam (4-ClDzp), a well-known ligand of the mitochondrial benzodiazepine receptor, on the physiology of both isolated cardiomyocytes and intact hearts.
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