Open AccessEndocytosis machinery is required for β1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes
Author(s) -
Carmine Morisco,
Chiara Marrone,
Jonathan Galeotti,
Dan Shao,
Dorothy E. Vatner,
Stephen F. Vatner,
Junichi Sadoshima
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvn008
Subject(s) - endocytosis , endocrinology , medicine , protein kinase b , muscle hypertrophy , biology , myocyte , downregulation and upregulation , phosphorylation , microbiology and biotechnology , receptor , biochemistry , gene
Cardiac hypertrophy by activation of the beta-adrenergic receptor (beta AR) is mediated more efficiently by the beta1-AR than by the beta2-AR. We investigated the signalling mechanism by which the beta1-AR mediates cardiac hypertrophy.
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