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The premetrological (preanalytical) phase is a recognized potential source of variation (1) that includes the variation attributable to sample collection, handling, centrifugation, and storage conditions. It is widely accepted that premetrological variation is negligible if all the processes included are standardized appropriately (2). However, there are few laboratories, if any, that can demonstrate this assumption in real day-to-day laboratory work. The aim of this study was to quantify the premetrological variation of some biochemical measurements related to the thyroid gland.Blood specimens were obtained from 20 volunteers from our laboratory staff. …

Premetrological Variation of Thyrotropin, Thyroxine (Non-Protein Bound), and Triiodothyronine Concentrations in Serum