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Premature rupture of the membranes (PROM), defined as rupture of the chorioamniotic membranes before the onset of labor, is a very common clinical problem in human pregnancy. In clinical obstetric terminology, PROM is defined as rupture of the membranes at term (within 3 weeks of the Estimated Date of Confinement, or due date). The reported incidence of PROM in term pregnancy is 8–10%. Approximately one-fourth of PROM cases occur remote from term (i.e., at less than 37 completed gestational weeks) and are termed preterm PROM (often called PPROM).Term pregnancies complicated by PROM are at increased risk for several complications for mother and fetus. The likelihood of ascending maternal infection, or chorioamnionitis, is directly related to the duration of membrane rupture, increasing from an overall rate of 0.5% to 3–15% with progressive duration of PROM (1). The risk of neonatal sepsis (0.2% for all term newborns) also increases both with the presence of PROM (1%) and with the duration of PROM (3–5% with …

Ceruloplasmin and Preterm Premature Rupture of the Membranes