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Regular readers of JAMA will have noted an on-going series with the catchy title “Users’ Guide to the Medical Literature” emanating from the Evidence-Based Medicine Working Group. One article from the series [Jaeschke R, Guyatt GH, Sackett DL. Users guide to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? JAMA 1994;271:703–7] would be of particular interest to readers of Clinical Chemistry and has important implications for all clinical laboratory workers who interface with clinicians. If a Bayesian cardiologist were to inquire about the likelihood ratio for different concentrations of CK-MB or troponin following an infarction, could the laboratory scientist provide this information or know …

clinical chemistry

Evidence-Based Medicine—How to Practice and Teach EBM. D. L. Sackett, W. S. Richardson, W. Rosenberg, and R. B. Haynes. New York: Churchill Livingstone, 1997, 250 pp. Paperback, $24.99. ISBN 0-443-05686-2.