Open AccessHigher serum galactose-deficient immunoglobulin A1 concentration is associated with stronger mesangial cellular inflammatory response and more severe histologic findings in immunoglobulin A nephropathy
Author(s) -
Celine Nguyen,
Katrin König,
Frederick W.K. Tam,
Helmut Hopfer,
Karen Molyneux,
Françoise-Isabelle Binet,
Min Jeong Kim
Publication year - 2018
Publication title -
clinical kidney journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.033
H-Index - 40
eISSN - 2048-8513
pISSN - 2048-8505
DOI - 10.1093/ckj/sfy068
Subject(s) - antibody , nephropathy , immunoglobulin g , immunology , immunoglobulin a , immunoglobulin m , medicine , endocrinology , diabetes mellitus
Galactose-deficient immunoglobulin A1 (Gd-IgA1) is known to play a key role in the pathogenesis of IgA nephropathy (IgAN). We aimed to evaluate whether serum Gd-IgA1 is associated with in vitro activation of mesangial cells in individual patients and how this affects the clinical and histologic parameters.
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