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Levonorgestrel subdermal implants are preferred contraceptives with an expected failure rate of &lt;1% over 5 years. We assessed the effect of efavirenz- or nevirapine-based antiretroviral therapy (ART) coadministration on levonorgestrel pharmacokinetics.

clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)

Unintended Pregnancies Observed With Combined Use of the Levonorgestrel Contraceptive Implant and Efavirenz-based Antiretroviral Therapy: A Three-Arm Pharmacokinetic Evaluation Over 48 Weeks