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Background Transmission of covid-19 can occur through inhalation of fine droplets or aerosols containing infectious virus. The objective of this study was to identify situations, patient characteristics, environmental parameters and aerosol-generating procedures (AGPs) associated with airborne SARS-CoV-2 virus. Methods Air samples were collected near hospitalised covid-19 patients and analysed by RT-qPCR. Results were related to distance to the patient, most recent patient diagnostic PCR Ct-value, room ventilation and ongoing potential AGP. Results In total 310 air samples were collected, and of these 26 (8%) were positive. Of the 231 samples from patient rooms, 22 (10%) were positive for SARS-CoV-2. Positive air samples were associated with a low patient Ct-value (OR 5.0 for a Ct-value &amp;lt;25 vs &amp;gt;25, p=0.01, 95% confidence interval 1.18 to 29.5) and a shorter physical distance to the patient (OR 2.0 for every meter closer to the patient, p=0.05, CI 1.0 to 3.8). A mobile HEPA-filtration unit in the room decreased the proportion of positive samples (OR 0.3, p=0.02, CI 0.12 to 0.98). No association was observed between SARS-CoV-2 positive air samples and mechanical ventilation, high flow nasal cannula, nebulizer treatment or non-invasive ventilation. An association was found with positive expiratory pressure (PEP) training (p&amp;lt;0.01) and a trend towards association for airway manipulation, including bronchoscopies and in- and extubations. Conclusions Our results show that major risk factors for airborne SARS-CoV-2 include short physical distance, high patient viral load and poor room ventilation. AGPs, as traditionally defined, seem to be of secondary importance.

clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)

Airborne Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Hospitals: Effects of Aerosol-Generating Procedures, HEPA-Filtration Units, Patient Viral Load, and Physical Distance