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In the CREDIBLE-CR and APEKS-NP studies, cefiderocol treatment was effective against Gram-negative bacteria producing metallo-beta-lactamases; rates of clinical cure (70.8% [17/24]), microbiological eradication (58.3% [14/24]), and Day-28 all-cause mortality (12.5% [3/24]) compared favorably with comparators of best available therapy and high-dose meropenem (40.0% [4/10]; 30.0% [3/10]; 50.0% [5/10]), respectively.

Cefiderocol for the Treatment of Infections Due to Metallo-B-lactamase–Producing Pathogens in the CREDIBLE-CR and APEKS-NP Phase 3 Randomized Studies