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1,6- O,O -Diacetylbritannilactone is a natural sesquiterpene lactone isolated from  Inula britannica  that has displayed cytotoxic effects against several human cancer cell lines. In this study, a selective and sensitive liquid chromatography–tandem mass spectrometry (LC–MS-MS) method was developed for determination of 1,6- O,O -diacetylbritannilactone in rat plasma. Chromatographic separation was achieved on an Agilent C 18  column (4.6 mm × 75 mm, 3.5 μm) with methanol and water (80:20,  v / v ) as the mobile phase. An ESI source was applied and operated in positive ion mode; selected-reaction monitoring was used for quantification using target fragment ions  m / z  373.2→312.9 for 1,6- O,O -diacetylbritannilactone and  m / z  331.2→144.1 for the IS. Calibration plots were linear in the range of 1.5–1350 ng/mL for 1,6- O,O -diacetylbritannilactone in rat plasma. Intra- and inter-day precisions were &lt;8.5%, and the accuracy ranged from −2.7 to 12.8%. The LC–MS-MS method was successfully applied in a pharmacokinetic study of 1,6- O,O -diacetylbritannilactone in rats.

A Sensitive LC–MS-MS Method for Quantification of 1,6- O,O -Diacetylbritannilactone in Rat Plasma and its Application in a Pharmacokinetic Study