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This study aims to study the changes of metabolism of Ephedra sinica Stapf caused by processing. A sensitive and rapid high-performance liquid chromatographic tandem mass spectrometry (LC-MS-MS) method was developed for the quantitation of the major metabolite of ephedrine, 4-hydroxyephedrine, utilizing lidocaine as the internal standard in rat urine. Urine samples were precipitated with acetonitrile. Chromatographic separation was achieved on an Ultimate C18 analytical column. Detection was performed by a multiple reaction monitoring mode via an electrospray ionization source operating in the positive ionization mode. The method was linear over the concentration range of 0.05-1.0c for all components. The intra- and inter-day precision values were &lt;13.2% and the deviations ranged from -8.4% to 7.5%. The recoveries at three levels were more than 66.2%. The fully validated method was used to study the pharmacokinetic profile of 4-hydroxyephedrine in rat urine to investigate the effects caused by processing.

journal of chromatographic science

Determination of the Metabolite of Ephedrine, 4-Hydroxyephedrine, by LC–MS-MS in Rat Urine and Its Application in Excretion Profiles After Oral Administration of<i>Ephedra sinica Stapf</i>and Processing<i>Ephedra sinica Stapf</i>

Determination of the Metabolite of Ephedrine, 4-Hydroxyephedrine, by LC–MS-MS in Rat Urine and Its Application in Excretion Profiles After Oral Administration ofEphedra sinica Stapfand ProcessingEphedra sinica Stapf