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The stimulating herbal drug khat (cathine, cathinone) and its analog methcathinone are common substances of abuse in most countries. A GC–MS method was developed and validated for the detection and quantification of cathine, cathinone, methcathinone and ephedrine in oral fluid specimens. The analytes and internal standard (amphetamine-d 5 ) were extracted from 0.5 mL oral fluids by ethyl acetate, and then the dried extracts were derivatized with heptafluorobutyric anhydride at 70°C for 30 min. The MS was used in selected ion monitoring mode. Ions monitored were  m / z  117, 240 and 330 for cathine,  m / z  77, 105 and 240 for cathinone,  m / z  105, 210 and 254 for methcathinone,  m / z  210, 254 and 344 for ephedrine and  m / z  244 and 336 for amphetamine-d 5 . The calibration curves were linear ( r  2 &gt; 0.98) in the concentration range 20–2,000 ng/mL for all analytes. The intra- and inter-assay imprecisions were within (1.6–12.5%) and (1.5–9.5%), respectively, for all analytes. Intra-assay accuracies were between −5.9 and 6.7% for all analytes. The method was successfully applied to detect and quantify the target analytes from oral fluid specimens collected from Khat and methcathinone users.

A GC–MS Method for Detection and Quantification of Cathine, Cathinone, Methcathinone and Ephedrine in Oral Fluid