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A high-performance liquid chromatography method was established for determination of 3,4-dihydroxy methyl benzoate in rat plasma and for investigation of pharmacokinetics after intragastric administration of 3,4-dihydroxy methyl benzoate water solution. 3,4-Dihydroxy methyl benzoate and internal standard were separated on a Diamonsil TM  C 18  column (250 mm × 4.6 mm, 5 µm), using a mobile phase of methanol–acetonitrile–water–glacial acetic acid (6 : 3 : 100 : 0.25, v/v/v/v), and the detection wavelength was 254 nm. The calibration curve of 3,4-dihydroxy methyl benzoate was linear in the concentration range of 0.1313–25.25 µg mL −1 . The lower limit of quantification was 0.1313 µg mL −1 , and the relative standard deviations of intra- and inter-day were &lt;11.7%. The main pharmacokinetic parameters were as follows:  C  max  (12.1 ± 1.93) mg L −1 ,  T  max  (27.5 ± 6.12) h,  t  1/2  (39.2 ± 5.66) h, AUC 0→ t  (0.85 ± 0.13) g min L −1 , AUC 0→∞  (0.88 ± 0.14) g min L −1 , MRT (70.7 ± 5.27) min −1 , Vd (0.32 ± 0.04) L and CL (5.79 ± 0.82) mL min −1 . The method is proven to be suitable for the pharmacokinetic study of 3,4-dihydroxy methyl benzoate, which offers the advantage of simplicity, sensitivity and accuracy.

Determination of 3,4-Dihydroxy Methyl Benzoate in Rat Plasma by HPLC and Its Pharmacokinetics