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Methylseleno- l -cysteine ( l -SeMC) is a naturally occurring amino acid analogue used as a general dietary supplement and is being explored as a chemopreventive agent. As a known dietary supplement,  l -SeMC is not regulated as a pharmaceutical and there is a paucity of analytical methods available. To address the lack of methodology, a stability-indicating method was developed and validated to evaluate  l -SeMC as both the bulk drug and formulated drug product (400 µg Se/capsule). The analytical approach presented is a simple, nonderivatization method that utilizes HPLC with ultraviolet detection at 220 nm. A C18 column with a volatile ion-pair agent and methanol mobile phase was used for the separation. The method accuracy was 99–100% from 0.05 to 0.15 mg/mL  l -SeMC for the bulk drug, and 98–99% from 0.075 to 0.15 mg/mL  l -SeMC for the drug product. Method precision was &lt;1% for the bulk drug and was 3% for the drug product. The LOQ was 0.1 µg/mL  l -SeMC or 0.002 µg  l -SeMC on column.

Validation of a Stability-Indicating Method for Methylseleno- l -Cysteine ( l -SeMC)