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A simple and selective liquid chromatography–tandem mass spectrometric method for determination of valtrate in rat plasma was developed in this study. Chromatographic separation was achieved on a Thermo BDS HYPERSIL C 18  column using acetonitrile–water–formic acid (75 : 25 : 0.1, v/v/v) as mobile phase in an isocratic mode of elution at a flow rate of 300 µL/min. MS–MS detection was performed in a positive ion electrospray ionization mode with the ion transitions 445.2 → 219.2 for valtrate and 355.2 → 135.1 for internal standard (sesamin). The developed method exhibited a linear dynamic range over 5.65–1695 ng/mL for valtrate in rat plasma. The overall extraction recovery of valtrate from plasma was 86.13–88.32%. The intra- and inter-day accuracy and precision were within the pre-defined limits of ≤15% at all concentrations. The method was successfully applied to pharmacokinetic studies of valtrate in rats.

Development of a LC–MS-MS Method for Quantification of Valtrate and Its Application to Pharmacokinetic Study