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A novel vortex-assisted surfactant-enhanced dispersive liquid–liquid microextraction combined with high-performance liquid chromatography (VASEDLLME–HPLC) was developed for the determination of thymol and carvacrol (phenolic compound). In this method, the extraction solvent (CHCl 3 ) was dispersed into the aqueous samples via a vortex agitator and addition of the surfactant (Triton X-100). The preliminary experiments were undertaken to select the best extraction solvent and surfactant. The influences of effective variables were investigated using a Plackett–Burman 2 7–4  screening design and then, the significant variables were optimized by using a central composite design combined with desirability function. Working under optimum conditions specified as: 140 µL CHCl 3 , 0.08% (w/v, Triton X-100), 3 min extraction time, 6 min centrifugation at 4,500 rpm, pH 7, 0.0% (w/v) NaCl permit achievement of high and reasonable linear range over 0.005–4.0 mg L −1  with  R  2  = 0.9998 ( n  = 10). The separation of thymol and carvacrol was achieved in &lt;14 min using a C 18  column and an isocratic binary mobile phase acetonitrile–water (55:45, v/v) with a flow rate of 1.0 mL min −1 . The VASEDLLME is applied for successful determination of carvacrol and thymol in different thyme and pharmaceutical samples with relative standard deviation &lt;4.7% ( n  = 5).

journal of chromatographic science

Application of Optimized Vortex-Assisted Surfactant-Enhanced DLLME for Preconcentration of Thymol and Carvacrol, and Their Determination by HPLC-UV: Response Surface Methodology