English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

The lipophilicity of anticancer and immunosuppressant active 1,8-diazaphenothiazine derivatives ( 1 – 16 ) has been investigated. Their lipophilicity ( R  M0  and log  P  TLC ) was determined by reversed-phase thin-layer chromatography with mixtures of acetone and TRIS buffer as mobile phases. The parameter  R  M0  and specific hydrophobic surface area  b  were significantly intercorrelated showing congeneric classes of dipyridothiazines. The parameter  R  M0  was discussed in the terms of the structure–lipophilicity relationships and transformed into parameter log  P  TLC  by use of the calibration curve. The lipophilicity was correlated with molecular and biomolecular descriptors (human intestinal absorption, blood–brain barrier, plasma protein binding, MDCK) and  in vitro  tumor necrosis factor alpha inhibition and antiproliferative activity.

Estimation of the Lipophilicity of New Anticancer and Immunosuppressive 1,8-Diazaphenothiazine Derivatives †