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A practical method using ultra-fast liquid chromatography in tandem with quadrupole time-of-ight mass spectrometry combined with dynamic background subtraction technology was developed for the rapid separation and identication of the complicated constituents in the  Shensong Yangxin  capsule (SSYX). The chromatographic separation was performed on a C18 column (2.1 × 100 mm, 2.6 μm) with a gradient elution program using methanol and 0.1% formic acid aqueous solution as the mobile phase at a ow rate of 0.4 mL min −1 . Accurate mass measurements of the molecular ions in the full scan and the characteristic fragment ions triggered by information-dependent acquisition provided reliable identication criteria. Thus, 99 compounds, including saponins, phenolic acids, tanshinones, lignans, terpenoids, alkaloids and flavonoids, were unambiguously or tentatively identied in 40 min by comparing their retention times and accurate mass measurements for each molecular ion and its subsequent fragment ions with those of authentic standards or literature data. Simultaneously, all the compounds were further assigned to the individual raw materials. In conclusion, these results will provide a basis for quality control and further study of SSYX, and the proposed technique based on high-resolution mass spectrometry would be expected to be adaptable to the analysis of complicated constituents in various complex matrices.

journal of chromatographic science

Identiﬁcation of Multiple Constituents in Chinese Medicinal Prescription  Shensong Yangxin  Capsule by Ultra-Fast Liquid Chromatography Combined with Quadrupole Time-of-Flight Mass Spectrometry