Open AccessDevelopment and Validation of Chromatographic Methods for the Identification and Quantitation of Organic Compounds Leached from a Laminated Polyolefin Material
Author(s) -
Dennis Jenke,
Mitchell J. Poss,
James Story,
Alex Odufu,
David Zietlow,
Tom Tsilipetros
Publication year - 2004
Publication title -
journal of chromatographic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.362
H-Index - 56
eISSN - 1945-239X
pISSN - 0021-9665
DOI - 10.1093/chromsci/42.7.388
Subject(s) - polyolefin , chemistry , chromatography , chromatographic separation , identification (biology) , organic chemistry , high performance liquid chromatography , botany , layer (electronics) , biology
Chromatographic methods for the identification of organic compounds leached from a plastic material used in solution containers in the pharmaceutical industry are described. Based on a set of compounds identified in extracts of a multilayered polyolefin film, targeted leachables are delineated for accumulation assessments, and methods to perform target quantitation are developed and validated.