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Tinuvin 770 [bis(2,2,6,6-tetramethyl-4-piperidinyl)sebacate] is a pharmacologically active agent used worldwide as a light stabilizer for plastic materials. In vitro studies show that it is an L-type Ca(2+) channel and neuronal nicotic acethylcholine receptor blocker. Hypotension, vegetative dysfunction, and neurological symptoms are frequently observed during a haemodialysis treatment. The release of Tinuvin 770 from plastic materials applied in haemodialysis may play a part in the development of clinical signs. In our study, four different commonly used haemodialysis membranes (polysulphon, cuprophan, and two types of hemophan) are examined. The polymers are soaked for 72 h in physiological saline solution. Isolation is carried out using a Waters Oasis SPE column for solid-phase extraction and by high-performance liquid chromatography (HPLC) with electrospray ionization-mass spectrometric detection. Tinuvin 770 release is detected from all examined membranes. Validation studies show a satisfactory selectivity, linearity, accuracy, and recovery of this method. Our results suggest that Tinuvin 770 could have specific toxicological and therapeutic importance related to haemodialysis treatment. The developed HPLC method is suitable for the detection of Tinuvin 770.

Detection of Tinuvin 770, A Light Stabilizer of Plastic Materials from Dialysis Membranes, by High-Performance Liquid Chromatographic Analysis